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天然分子薬化学研究室

Laboratory of Natural Products and Medicinal Chemistry

  

  

  

研究業績 2014年以降
Research Acheivments since 2014

2024

1. Koga N, Saito Y, Miyake K, Amuti S, Fukuyoshi S, Yoshida S, Sato S, Yamada Y,      Ikeda A, Adachi N, Kawasaki M, Takasu A, Aramaki S, Senda T, Rahim A, Najib      A, Alam G, Tanaka N, Nakagawa-Goto K,* Cyclic sesquiterpene-flavanone            [4+2] hybrids, Syzygioblanes A-C, found in an Indonesian traditional                    medicine, 'Jampu Salo' (Syzygium oblanceolatum), Org. Lett. 2024, ASAP.

2. Maeda S, Nakayama W, Saito Y, Sagano M, Goto M, Nakagawa-Goto K.* Total        Synthesis of a TNBC-selective Cytotoxic Bromo Nor-eremophilane, PC-A, and        Its Preliminary Structure-activity Relationships, J. Nat. Prod. 2024, 87, 861-        868. DOI:10.1021/acs.jnatprod.3c01075

3. Amuti S, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O’keefe BR., Lee, KH,          Nakagawa-Goto K.* Unusual Vilasinin-Class Limonoids from Trichilia rubescens,     Molecules, 2024, 29, 651. DOI:10.3390/molecules29030651

4. Kobayashi A, Saito Y, Miyake K, Fukuyoshi S, Newman DJ, O’Keefe BR, Lee KH,      Nakagawa-Goto K.* Caged xanthones and biphenyls isolated from a tropical        plant, Garcinia lateriflora, J. Nat. Prod. 2024, 87, 266-275.                                DOI:10.1021/acs.jnatprod.3c00934

2023

1. Yasir B, Rahim A, Lallo S, Saito Y, Nakagawa-Goto K, Roman A, Alam G.                Cytotoxicity activity, metabolite profiling, and isolation compound from crude        hexane extract of Cleome rutidospermae, Aisan Pac J Cancer Prev 2023, 24,        3345-3352. DOI:10.31557/APJCP.2023.24.10.3345

2. Shimoi R, Saito Y, Miura Y, Nakagawa-Goto K.* Total synthesis of waltherinone      A, a qunoline alkaloids fused with oxabicyclo[3.2.1]octane, Org. Lett. 2023,        25, 4755-4758. DOI:10.1021/acs.orglett.3c01837

3. Shimada R, Naito R, Toriumi R, Nakagawa R, Aoyama S, Kamijima T, Kano H,        Kadomoto S, Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Nakata H, Saito Y,          Nakagawa-Goto K, Mizokami A. Novel α-trifluoromethyl chalcone exerts                antitumor effects against prostate cancer cells, Anticancer Res. 2023, 43              2433-2444.  DOI: 10.21873/anticanres.16411

4. Rahim A, Amuti S, Najib A, Miyake K, Saito Y, Nakagawa-Goto K,* A new bis-        indole alkaloid, spermaocymine A, and an anthraquinone from Spermacoce          ocymoides, Chem. Pharm. Bull. 2023, 71, 380-384.                                            DOI: 10.1248/cpb.c23-00005

5. Kano H, Izumi K, Hiratsuka K, Toriumi R, Nakagawa R, Aoyama S, Kamijima T,      Shimada T, Naito R, Kadomoto S, Iwamoto H, Yaegashi H, Kawaguchi S,              Nohara T, Shigehara K, Kadono Y, Saito Y, Nakagawa-Goto K, Yoshioka K,              Nakata H, Lin W-J, Mizokami A, Suppression of androgen receptor signalin            induces prostate cancer migration via activation of the CCL20?CCR6 axis,              Cancer Science, 2023, 114, 1479-1490.DOI: 10.1111/cas.15683

6. Cheng YT, Nakagawa-Goto K, Lee KH, Shyur LF. MicroRNA-mediated                    mitochondrial dysfunction is involved in the anti-triple-negative breast cancer        cell activity of phytosesquiterpene lactones, Antioxid. Redox Signal. 2023, 38      198-214.  DOI: 10.1089/ars.2021.0251

2014-2022

論文(publications)       学会発表(presentations)

2022                                            2022 

2021                                            2021

2020                                            2020

2019                                            2019

2018                                            2018

2017                                            2017

2016~2014                                 2016~2014

特許・著書・その他(others)

Natural Products and Medicinal Chemistry

〒920-1192
Kakuma-machi, Kanazawa, Ishikawa