2021Posted by admin

 
Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst
Jie Liu, Hikaru Fujita, Masanori Kitamura, Daichi Shimada, Munetaka Kunishima
Organic & Biomolecular Chemistry Advance Article (DOI:10.1039/D1OB00450F)

A versatile iodo(III)etherification of terminal ethynylsilanes using BF3-OiPr2 and alkyl benzyl ethers
Takuya Matsumoto, Hiroshi Hagiyama, Kanetsugu Kuribayashi, Kazuhito Hioki, Hikaru Fujita, Masahito Ochiai, Munetaka Kunishima
Organic & Biomolecular Chemistry 19 pp.3825-3828 (DOI:10.1039/D1OB00479D)

2020Posted by admin

 
Development of hydrophilic polyacrylamide gel-based condensing reagents comprised of chlorotriazine
Kohei Yamada, Shota Hirozawa, Junqing Xia, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 68 (6) pp.534-537 (DOI:10.1248/cpb.c20-00074)
Trizaine-based dehydrative condensation reagents bearing carbon-substituents
Masanori Kitamura, Sayaka Komine, Kohei Yamada, Munetaka Kunishima
Tetrahedron 76 (12) pp.130900-130912 (DOI:10.1016/j.tet.2019.130900)

Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution
Kenji Mishiro, Mitsuki Nomura, Taniyuki Furuyama, Munetaka Kunishima
The Journal of Organic Chemistry 86 (4) pp.3625-3636 (DOI:10.1021/acs.joc.0c02997)

2019Posted by admin

 
Development of Triazinone-Based Condensing Reagents for Amide Formation
Kohei Yamada, Mika Kota, Kensuke Takahashi, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
The Journal of Organic Chemistry 84 (23) pp.15042-15051 (DOI:10.1021/acs.joc.9b01261)

Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-β-carbolines Using a Triazine-Based Activating Agent
Hikaru Fujita, Riho Nishikawa, Ozora Sasamoto, Masanori Kitamura, Munetaka Kunishima
The Journal of Organic Chemistry 84 (13) pp.8380-8391 (DOI:10.1021/acs.joc.9b00039)

Preparation of Alkyl Ethers with Diallyltriazinedione‐Type Alkylating Agents (ATTACKs‐R) Under Acid Catalysis
Hikaru Fujita, Rina Yamashita, Takanori Fujii, Kohei Yamada, Masanori Kitamura, Munetaka Kunishima
European Journal of Organic Chemistry (27) pp.4436-4446 (DOI:10.1002/ejoc.201900607)

Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts
Kenji Mishiro, Takeshi Kimura, Taniyuki Furuyama and Munetaka Kunishima
Organic Letters 21 (11) pp.4101-4105 (DOI:10.1021/acs.orglett.9b01280)

Development of a Storable Triazinone-Based Reagent for O-p-Methoxybenzylation under Mild Heating Conditions
Hikaru Fujita, Hiromitsu Terasaki, Satoshi Kakuyama, Kazuhito Hioki, and Munetaka Kunishima
Organic Letters 21 (9) pp. 3093-3097 (DOI: 10.1021/acs.orglett.9b00732)

2018Posted by admin

 
Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid
Kenji Mishiro, Yuki Yushima, and Munetaka Kunishima
The Journal of Organic Chemistry 83 (21), pp 13595-13603 (DOI: 10.1021/acs.joc.8b02250)

Development of triazine-based esterifying reagents containing pyridines as a nucleophilic catalyst
Kohei Yamada, Jie Liu and Munetaka Kunishima
Organic & Biomolecular Chemistry 16, pp. 6569-6575 (DOI: 10.1039/c8ob01660g)

Cooperation of the Neutral and the Cationic Leaving Group Pathways in Acid-Catalyzed O-Benzylation of TriBOT
Hikaru Fujita , Naoko Hayakawa, and Munetaka Kunishima
The Journal of Organic Chemistry 83 (17), pp 10684-10687 (DOI: 10.1021/acs.joc.8b01505)

Imido-substituted triazines as dehydrative condensing reagents for the chemoselective formation of amides in the presence of free hydroxy groups
Masanori Kitamura, Suguru Sasaki, Riho Nishikawa, Kohei Yamada and Munetaka Kunishima
RCS Advances 8, pp. 22482-22489 (DOI: 10.1039/c8ra03057j)

Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species
Hikaru Fujita, Satoshi Kakuyama, Shuichi Fukuyoshi, Naoko Hayakawa, Akifumi Oda, and Munetaka Kunishima
The Journal of Organic Chemistry 83 (8), pp 4568-4580 (DOI: 10.1021/acs.joc.8b00331)


Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma
Wen Jing Zhu, Masato Kobayashi, Kohei Yamada, Kodai Nishi, Kotaro Takahashi, Asuka Mizutani, Ryuichi Nishii, Leo G Flores II, Naoto Shikano, Munetaka Kunishima, Keiichi Kawai
Nuclear Medicine and Biology 59 pp. 16-21 (DOI: 10.1016/j.nucmedbio.2017.12.008)

An isolable and bench-stable epoxidizing reagent based on triazine: Triazox
Kohei Yamada, Yuki Igarashi, Tatsuki Betsuyaku, Masanori Kitamura, Koki Hirata, Kazuhito Hioki, Munetaka Kunishima
Organic Letters 20 (7) pp. 2015-2019 (DOI: 10.1021/acs.orglett.8b00560)

化学ポータルサイトChem-Stationで紹介されました。
Development of Triazine-Based Benzylating Reagents Possessing t-Butyl Group on the Triazine Core: Thermally Controllable Reagents for the Initiation of Reaction
Yukiko Karuo, Kohei Yamada, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 66 (3) pp. 303-308 (DOI: 10.1248/cpb.c17-00897)
Highlighted Paper selected by Editor-in-Chief

Development of highly electron-deficient and less sterically-hindered phosphine ligands possessing 1,3,5-triazinyl groups
Kazumi Abe, Masanori Kitamura, Hikaru Fujita, Munetaka Kunishima
Molecular Catalysis 445, pp. 87-93 (DOI: 10.1016/j.mcat.2017.11.008)

2017Posted by admin

 
Novel Alkylating Reagents Designed by the Characteristics of 1,3,5-Triazines
Munetaka Kunishima, Kohei Yamada, Hikaru Fujita, Masanori Kitamura
Journal of Synthetic Organic Chemistry, Japan
75 (10) pp.1023-1034 (DOI: 10.5059/yukigoseikyokaishi.75.1023)
Phototriggered Dehydration Condensation Using an Aminocyclopropenone
Kenji Mishiro, Yuki Yushima, Munetaka Kunishima
Organic letters 19 (18), pp 4912-4915 (DOI: 10.1021/acs.orglett.7b02383)

Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid
Yamada Kohei, Kamimura Naoto, Kunishima Munetaka
Beilstein Journal of Organic Chemistry 13, pp. 1478-1485 (DOI: 10.3762/bjoc.13.146)
N,N'-Dimethylated Benzyloxytriazinedione: A Stable Solid Reagent for Acid-Catalyzed O-Benzylation
Hikaru Fujita, Satoshi Kakuyama, Munetaka Kunishima
European Journal of Organic Chemistry (4), pp. 833-839 (DOI: 10.1002/ejoc.201601387)

Study of O-Allylation using Triazine-based Reagents
Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 65, pp. 112-115 (DOI: 10.1248/cpb.c16-00744)

2016Posted by admin

 
Alcohol- and Amine-Tolerant Synthesis of Six-Membered Cyclic Quaternary Ammonium Salts Using a Triazine-Based Reagent
Masanori Kitamura, Seina Yamamura, Kohei Yamada, Munetaka Kunishima
Asian Journal of Organic Chemistry 5 (12), pp. 1508-1517 (DOI: 10.1002/ajoc.201600429)

Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation
Kohei Yamada, Yukiko Karuo, Yuichi Tsukada, Munetaka Kunishima
Chemistry - A European Journal 22 (39), pp. 14042-14047 (DOI: 10.1002/chem.201603120)

Development of a Triazine-based tert-Butylating Reagent, TriAT-tBu
Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
European Journal of Organic Chemistry (23), pp. 4093-4098 (DOI: 10.1002/ejoc.201600663)

Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure
Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Masanori Kitamura, Munetaka Kunishima, Yasutsuna Sasaki, Yukio Kato
Pharmaceutical Research 33 (2), pp. 269-282 (DOI: 10.1007/s11095-015-1785-0)
Potent triazine-based dehydrocondensing reagents substituted by an amido group
Munetaka Kunishima, Daiki Kato, Nobu Kimura, Masanori Kitamura, Kohei Yamada, Kazuhito Hioki
Beilstein Journal of Organic Chemistry 12, pp. 1897-1903 (DOI: 10.3762/bjoc.12.179)

Development of Acid-Catalyzed Fluorous Benzylating Reagents Based on a Triazinedione Core
Munetaka Kunishima, Ryohei Asao, Kohei Yamada, Masanori Kitamura, Hikaru Fujita
Journal of Fluorine Chemistry 190, pp. 68-74 (DOI: 10.1016/j.jfluchem.2016.09.003)

2015Posted by admin

 
Study of the Reactivities of Acid-Catalyzed O-Benzylating Reagents Based on Structural Isomers of 1,3,5-Triazine
Hikaru Fujita, Naoko Hayakawa, and Munetaka Kunishima
Journal of Organic Chemistry 80 (21), pp. 11200-11205 (DOI: 10.1021/acs.joc.5b02059)

O-Benzylation of Carboxylic Acids Using 2,4,6-Tris(benzyloxy)-1,3,5-triazine (TriBOT) under Acidic or Thermal Conditions
Kohei Yamada, Saki Yoshida, Hikaru Fujita, Masanori Kitamura, and Munetaka Kunishima
European Journal of Organic Chemistry (36), pp. 7997-8002 (DOI: 10.1002/ejoc.201501172)

2014Posted by admin

 
Role of Linkers in Tertiary Amines that Mediate or Catalyze 1,3,5-Triazine-based Amide-forming Reactions
Masanori Kitamura, Fumitaka Kawasaki, Kouichi Ogawa, Shuichi Nakanishi, Hiroyuki Tanaka, Kohei Yamada, and Munetaka Kunishima
Journal of Organic Chemistry 79 (8), pp. 3709-3714 (DOI: 10.1021/jo500376m)

Synthesis of Pyrrolidinium Salts using a Triazine-based Reagent under Mild Conditions
Masanori Kitamura, Seina Yamamura, Hiroko Kobayashi, Mariko Yamamoto, Kayo Tada, Kazuhito Hioki, Kohei Yamada, and Munetaka Kunishima
Chemistry Letters 43 (10), pp. 1593-1595 (DOI: 10.1246/cl.140503)

Development of a New Benzylating Reagent Spontaneously Releasing Benzyl Cation Equivalents at Room Temperature
Kohei Yamada, Yuichi Tsukada, Yukiko Karuo, Masanori Kitamura, and Munetaka Kunishima
Chemistry - A European Journal 20 (38), pp. 12274-12278 (DOI: 10.1002/chem.201403158)
Specific Labeling of Streptavidin for Better Understanding of Ligand Modification in Modular Method for Affinity Labeling(MoAL)
Munetaka Kunishima, Daiki Kato, Shuichi Nakanishi, Masanori Kitamura, Kohei Yamada, Keiji Terao, and Tomoya Asano
Chemical and Pharmaceutical Bulletin 62 (11), pp. 1146-1150 (DOI: 10.1248/cpb.c14-00468)

2013Posted by admin

 
A Practical Method for p-Methoxybenzylation of Hydroxy Groups Using 2,4,6-Tris(p-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM)
Kohei Yamada, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
Synthesis 45 (21), pp. 2989-2997 (DOI: 10.1055/s-0033-1339713)
Study of 1,3,5-Triazine-Based Catalytic Amide-Forming Reactions: Effect of Solvents and Basicity of Reactants
Munetaka Kunishima, Masanori Kitamura, Hiroyuki Tanaka, Ichiro Nakakura, Takahiro Moriya, Kazuhito Hioki
Chemical and Pharmaceutical Bulletin 61 (8), pp. 882-886 (DOI: 10.1248/cpb.c13-00368)
Binding of sulforhodamine B to human serum albumin: A spectroscopic study
Masanori Kitamura, Koji Murakami, Kohei Yamada, Keiichi Kawai, Munetaka Kunishima
Dyes and Pigments 99, pp. 588-593 (DOI: 10.1016/j.dyepig.2013.06.011)

A New Method Using 2-Chloro-4,6-dimethoxy-1,3,5-triazine for Facile Elimination of Dimethylamino Group in Eschenmoser’s Methylenation for Synthesis of α,β-Unsaturated Esters
Kohei Yamada, Kazumasa Masaki, Yuri Hagimoto, Seina Kamiya, Munetaka Kunishima
Tetrahedron Letters 54, pp. 1758-1760 (DOI: 10.1016/j.tetlet.2013.01.092)

2012Posted by admin

 
Study on 1,3,5-Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species
Munetaka Kunishima, Takae Ujigawa, Yoshie Nagaoka, Chiho Kawachi, Kazuhito Hioki, Motoo Shiro
Chemistry - A European Journal 18, pp. 15856-15867 (DOI: 10.1002/chem.201202236.)
A novel acid-catalyzed O-benzylating reagent with the smallest unit of imidate structure
Kohei Yamada, Hikaru Fujita, Munetaka Kunishima
Organic Letters 14 (19), pp. 5026-5029 (DOI: 10.1021/ol302222p)
One-pot preparation of oxazol-5(4H)-ones from amino acids in aqueous solvents
Hikaru Fujita, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 60 (7), pp. 907-912 (DOI: 10.1248/cpb.c12-00291)

N-isopropyl-p-iodoamphetamine hydrochloride is predominantly metabolized by CYP2C19
Ken-ichi Fujita, Minako Sugiyama, Yuko Akiyama, Kazuhito Hioki, Munetaka Kunishima, Kodai Nishi, Masato Kobayashi, Keiichi Kawai and Yasutsuna Sasaki
Drug Metabolism and Disposition 40 (5), pp. 843-846 (DOI: 10.1124/dmd.111.043893)
Substrate-selective dehydrocondensation at the interface of micelles and emulsions of common surfactants
Kunishima, M., Kikuchi, K., Kawai, Y., Hioki, K.
Angewandte Chemie International Edition 51 (9), pp. 2080-2083 (DOI: 10.1002/anie.201107706)

2011Posted by admin

 
New approach to oligotriazoles using a cobalt complex of propargyl azides as a synthetic component
Yuichi Tsukada, Kohei Yamada, Munetaka Kunishima
Tetrahedron Letters 52 (26), pp. 3358-3360 (DOI: 10.1016/j.tetlet.2011.04.082)

2010Posted by admin

 
Labeling study of avidin by modular method for affinity labeling (MoAL)
Shuichi Nakanishi, Hiroyuki Tanaka, Kazuhito Hioki, Kohei Yamada, Munetaka Kunishima
Bioorganic and Medicinal Chemistry Letters 20 (23), pp. 7050-7053 (DOI: 10.1016/j.bmcl.2010.09.109)
Effects of stereochemistry and β-substituents on the rates of vinylic SN2 reaction of hypervalent vinyl(phenyl)-λ3-iodanes with tetrabutylammonium halides
Kazunori Miyamoto, Takuji Okubo, Masaya Hirobe, Munetaka Kunishima, Masahito Ochiai
Tetrahedron 66 (31), pp. 5819-5826 (DOI: 10.1016/j.tet.2010.04.041)

2009Posted by admin

 
Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation
Munetaka Kunishima, Shuichi Nakanishi, Jin Nishida, Hiroyuki Tanaka, Daiki Morisaki, Kazuhito Hioki, Hiroshi Nomoto
Chemical Communications (37), pp. 5597-5599 (DOI: 10.1039/B912908A)
Synthesis of aza-bridged calix(4-methoxy)triazines toward flattened π-conjugated macrocycles
Hiroyuki Tanaka, Ayako Wada, Motoo Shiro, Kazuhito Hioki, Daiki Morisaki, and Munetaka Kunishima
Heterocycles 79 (C), pp. 609-616 (DOI: 10.3987/COM-08-S(D)24)
A Simple Practical Method for the Synthesis of 4,6-Dimethoxy-1,3,5-triazin-2(1H)-one Using Dimethylamine-Functionalized Solid-Phase Reagents
Kazuhito Hioki, Keiichi Ohshima, Yuko Sota, Miki Tanaka, Munetaka Kunishima
Synthesis (4), pp. 542-544 (DOI: 10.1055/s-0028-1083330)