原著論文　学会発表　研究費獲得状況　学位論文

Shahnaij M, Iyori M, Mizukami H, Kajino M, Yamagoshi I, Syafira I, Yusuf Y, Fujiwara K, Yamamoto DS, Kato H, Ohno N, Yoshida S.
Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model.
Front Immunol.,  12:612910, 2021.
PMID:34248928

Iyori M, Ogawa R, Emran TB, Tanbo S, Yoshida S.
Characterization of the gene expression patterns in the murine liver following intramuscular administration of baculovirus.
Gene  Expr., 20(3):147-155, 2020.
PMID:33115550

Yusuf Y, Yoshii T, Iyori M, Mizukami H, Fukumoto S, Yamamoto DS, Emran TB, Amelia F, Islam A, Syafira I, Yoshida S.
A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies.
Front Immunol., 10:2412, 2019.
PMID:31681301

Yusuf Y, Yoshii T, Iyori M, Yoshida K, Mizukami H, Fukumoto S, Yamamoto DS, Alam A, Emran TB, Amelia F, Islam A, Otsuka H, Takashima E, Tsuboi T, Yoshida S.
Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming.
Front Immunol., 10:730, 2019.
PMID:31024558

Amelia F, Iyori M, Emran TB, Yamamoto DS, Genshi K, Otsuka H, One Y, Yusuf Y, Islam A, Yoshida S.
Down‐selecting circumsporozoite protein‐based malaria vaccine: a comparison of malaria sporozoite challenge model.
Parasite Immunol., e12624, 2019.
PMID: 30883819

Islam A, Emran TB, Yamamoto DS, Iyori M, Amelia F, Yusuf Y, Yamaguchi R, Alam MS, Silveira H, Yoshida S.
Anopheline antiplatelet protein from mosquito saliva regulates blood feeding behavior.
Sci Rep., 9(1):3129, 2019.
PMID: 30816309

Emran TB, Iyori M, Ono Y, Amelia F, Yusuf Y, Islam A, Alam A, Tamura M, Ogawa R, Matsuoka H, Yamamoto DS, Yoshida S.
Baculovirus-induced fast-acting innate immunity kills liver-stage Plasmodium.
J. Immunol., 201(8):2441-2451, 2018.
PMID: 30209187

Yoshida K, Iyori M, Blagborough AM, Salman AM, Dulal P, Sala KA, Yamamoto DS, Khan SM, Janse CJ, Biswas S, Yoshii T, Yusuf Y, Tokoro M, Hill AVS, Yoshida S.
Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model.
Sci Rep., 8(1):3896, 2018.
PMID: 29497047

Iyori M, Blagborough AM, Sala KA, Nishiura H, Takagi K, Yoshida S.
Protective efficacy of an IL-12-expressing baculoviral malaria vaccine.
Parasite Immunol., 39(12):12498, 2017.
PMID: 29072334

Iyori M, Yamamoto DS, Sakaguchi M, Mizutani M, Ogata S, Nishiura H, Tamura T, Matsuoka H, Yoshida S.
DAF-shielded baculovirus-vectored vaccine enhances protection against malaria sporozoite challenge in mice.
Malar J, 16:390, 2017.
PMID: 28962615

Mizutani M, Fukumoto S, Soubeiga AP, Soga A, Iyori M, Yoshida S.
Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model.
Malar J, 15(1):251, 2016.
PMID: 27129682

Tamura T, Kawabata C, Matsushita S, Sakaguchi M, Yoshida S.
Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes.
J Gene Med., 18(4-6):75-85, 2016.
PMID: 27007512

Tamura T, Kimura K, Yui K, Yoshida S.
Reduction of conventional dendritic cells during Plasmodium infection is dependent on activation induced cell death by type I and II interferons.
Exp Parasitol., 159:127-35, 2015.
PMID: 26420463

Sala K.*, Nishiura H.*, Upton L., Zakutansky S., Delves M., Iyori M., Mizutani M., Sinden RE., Yoshida S., Blagborough AM. :
The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro.
Vaccine, 33(3):437-45, 2014. (*equal contribution)
PMID: 25454088

Mizutani M., Iyori M., Blagborough AM., Fukumoto S., Funatsu T., Sinden RE, Yoshida S. :
Baculovirus-Vectored Multistage Plasmodium vivax Vaccine Induces Both Protective and Transmission-blocking Immunities against Transgenic Rodent Malaria Parasites.
Infect. Immunol., 82(10):4348-57, 2014.
PMID: 25092912

Sugiyama K*, Iyori M*, Sawaguchi A, Akashi S, Tame JRH, Park SY, Yoshida S. :
The crystal structure of the active domain of Anopheles anti-platelet protein, a powerful anti-coagulant, in complex with an antibody.
J. Biol. Chem., 289(23):16303-16312., 2014. (*equal contribution)
PMID: 24764297

Tamura T, Akbari M, Kimura K, Kimura D, Yui K.:
Flt3 ligand treatment modulates parasitemia during infection with rodent malaria parasites via MyD88- and IFN-γ-dependent mechanisms.
Parasite Immunol 36(2):87-99, 2014.
PMID: 24400637

Yamamoto DS, Yokomine T, Sumitani M, Yagi K, Matsuoka H, Yoshida S.:
Visualization and live imaging analysis of a mosquito saliva protein in host animal skin using a transgenic mosquito with a secreted luciferase reporter system.
Insect Mol Biol In press, 2013.
PMID: 24118655

Iyori M, Nakaya H, Inagaki K, Pichyangkul S, Yamamoto DS, Kawasaki M, Kwak K, Mizukoshi M, Goto Y, Matsuoka M, Matsumoto M, Yoshida S. :
Protective Efficacy of Baculovirus Dual Expression System Vaccine Expressing Plasmodium falciparum Circumsporozoite Protein.
PLOS ONE 8(8):e70819, 2013.
PMID: 23951015

Kamei R, Miyakoda M, Tamura T, Kimura D, Honma K, Kimura K, Yui K.:
Accumulation of major histocompatibility complex class II(+)CD11c(-) non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent.
Microbiol Immunol 57(3):213-23, 2013.
PMID: 23278848

Mizutani M, Mukaiyama K, Xiao J, Mori M, Satou R, Narita S, Okuda S, Tokuda H.:
Functional differentiation of structurally similar membrane subunits of the ABC transporter LolCDE complex.
FEBS Lett 587(1):23-9, 2012.
PMID: 23187171

Sumitani M, Kasashima K, Yamamoto DS, Yagi K, Yuda M, Matsuoka H, Yoshida S.:
Reduction of malaria transmission by transgenic mosquitoes expressing an antisporozoite antibody in their salivary glands.
Insect Mol Biol 22(1):41-51, 2013.
PMID: 23176559

Yamamoto DS, Sumitani M, Nagumo H, Yoshida S, Matsuoka H.:
Induction of antisporozoite antibodies by biting of transgenic Anopheles stephensi delivering malarial antigen via blood feeding.
Insect Mol Biol 21(2):223-33, 2012.
PMID: 22787718

Hayashi H, Kyushiki H, Nagano K, Sudo T, Iyori M, Matsuoka H, Yoshida S.:
Identification of the active region responsible for the anti-thrombotic activity of anopheline anti-platelet protein from a malaria vector mosquito.
Platelets 24(4):324-32, 2012.
PMID: 22738392

Shimizu Y, Yamazaki H, Yoshida S, Yonekura M, Kouzuma Y.:
Molecular Cloning, Functional Expression, and Characterization of Isolectin Genes of Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata.
Bioscience, Biotechnology, and Biochemistry 76(2):276-82, 2012.
PMID: 22313748

Hayashi H, Kyushiki H, Nagano K, Sudo T, Matsuoka H, Yoshida S.:
Anopheline anti-platelet protein from a malaria vector mosquito has anti-thrombotic effects in vivo without compromising hemostasis.
Thromb Res 129(2):169-75, 2012.
PMID: 21986215

Ohtani M, Iyori M, Saeki A, Tanizume N, Into T, Hasebe A, Totsuka Y, Shibata KI.:
Involvement of suppressor of cytokine signaling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signaling by the murine C-type lectin SIGNR1-mediated signaling.
Cell Microbiol 14(1):40-57, 2012.
PMID: 21899704

Tamura T, Kimura K, Yuda M, Yui K.:
Prevention of experimental cerebral malaria by Flt3 ligand during infection with Plasmodium berghei ANKA.
Infect Immu 79(10):3947-56, 2011.
PMID: 21807908

Iyori M, Zhang T, Pantel H, Gagne BA, Sentman CL.:
TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells.
J Immunol 187(6):3087-95, 2011.
PMID: 21832159

Arai T, Kimata I, Kitade Y, Nakamoto K, Tokoro M.:
In vitro assessment of anticryptosporidial efficacy and cytotoxicity of adenosine analogues using a SYBR Green real-time PCR method.
J Antimicrob Chemother 66(3):560-3, 2011.
PMID: 21393228

Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Inoue Y, Matsumoto M, McMurray DN, De la Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M.:
Novel therapeutic vaccine: granulysin and new DNA vaccine against Tuberculosis.
Hum Vaccin 7 Suppl:60-7, 2011.
PMID: 21546794

Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Inoue Y, McMurray DN, Sakatani M.:
Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis.
Clin Dev Immunol 2011:549281, 2011.
PMID: 21437226

Kita Y, Okada M, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Kishigami C, Nishimatsu S, Sekine Y, Takamori Y, McMurray DN, Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M. :
Development of therapeutic and prophylactic vaccine against Tuberculosis using monkey and transgenic mice models.
Hum Vaccin 7 Suppl:108-14, 2011.
PMID: 21263229

Mlambo G, Kumar N, Yoshida S. :
Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmission-blocking vaccine candidate antigen.
Vaccine 28:7025-9, 2011.
PMID: 20709008

Yoshida S, Nagumo H, Yokomine T, Araki H, Suzuki A, Matsuoka H. :
Plasmodium berghei circumvents immune responses induced by merozoite surface protein 1- and apical membrane antigen 1-based vaccines.
PLoS One 5:e13727, 2010.
PMID: 21060850

Shamsul HM, Hasebe A, Iyori M, Ohtani M, Kiura K, Zhang D, Totsuka Y, Shibata K.:
The Toll-like receptor 2 (TLR2) ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2 .
Immunology 130(2):262-72, 2010.
PMID: 20113368

Blagborough AM, Yoshida S, Sattabongkot J, Tsuboi T, Sinden RE. :
Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission.
Vaccine 28:6014-20, 2010.
PMID: 20637303

Tamura T, Chiba J.:
Production of antibodies against multipass membrane proteins expressed in human tumor cells using dendritic cell immunization.
J Biomed Biotechnol 2009:673098, 2009.
PMID: 19390695

Tamura T, Chiba J.:
STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells.
Int J Mol Med 24(5):599-604, 2009.
PMID: 19787193

Yoshida S, Araki H, Yokomine T. :
Baculovirus-based nasal drop vaccine confers complete protection against malaria by natural boosting of vaccine-induced antibodies in mice.
Infect Immun 78:595-602, 2009.
PMID: 19901059

Yoshida S, Kawasaki M, Hariguchi N, Hirota K, Matsumoto M.
A baculovirus dual expression system-based malaria vaccine induces strong protection against Plasmodium berghei sporozoite challenge in mice.:
Infect Immun 77:1782-9, 2009.
PMID: 19223476

Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Inoue Y, Matsumoto M, McMurray DN, Dela Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M. :
Novel prophylactic and therapeutic vaccine against tuberculosis.
Vaccine 27(25-26):3267-70, 2009.
PMID: 19200841

Iyori M, Ohtani M, Hasebe A, Totsuka Y, Shibata K.:
A role of the Ca2+ binding site of DC-SIGN in the phagocytosis of E. coli.
Biochem Biophys Res Commun 377(2):367-72, 2008.
PMID: 18848918

Yoshida S, Sudo T, Niimi M, Tao L, Sun B, Kambayashi J, Watanabe H, Enjou L, Matsuoka H.:
Inhibition of collagen-induced platelet aggregation by anopheline anti-platelet protein, a saliva protein from a malaria vector mosquito.
Blood 111:2007-14, 2008.
PMID: 18056842

Iyori M, Kataoka H, Shamsul HM, Kiura K, Yasuda M, Nakata T, Hasebe A, Shibata K.:
Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program.
Antimicrob Agents Chemother 52(1):121-7, 2008.
PMID: 17938187

Yoshida S, Shimada Y, Kondoh D, Kouzuma Y, Ghosh AK, Jacobs-Lorena M, Sinden RE.:
Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development.
PLoS Pathogen 3:e192, 2007.
PMID: 18159942

Okada M, Okuno Y, Hashimoto S , Kita Y, Kanamaru N, Nishida Y, Tsunai Y, Inoue R, Nakatani H, Fukamizu R, Namie Y, Yamada J, Takao K, Asai R, Asaki R, Kase T, Takemoto Y, Yoshida S, Peiris JSM, Chen P-J, Yamamoto N, Nomura T, Ishida I, Morikawa S, Tashiro M, Sakatani M.:
Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.
Vaccine 25:3038-40, 2007.
PMID: 17289225

Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Fukamizu R, Tsunai Y, Inoue R, Nakatani H, Namie Y, Yamada J, Takao K, Asai R, Asaki R, Matsumoto M, McMurray D, Cruz D, Tan E, Abalus R, Burgos J, Gelber R, Sakatani M.:
Evaluation of a novel vaccine (HVJ-liposome/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB.
Vaccine 25:2990-3, 2007.
PMID: 17280753

Mae M*, Iyori M*,Yasuda M, Shamsul HM, Kataoka H, Kiura K, Hasebe A, Totsuka Y, Shibata K.:
The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway.
FEMS Immunol Med Microbiol 49(3):398-409, 2007. (*equal contribution)
PMID: 17316370

Kataoka H, Yasuda M, Iyori M, Kiura K, Narita M, Nakata T, Shibata K.:
Roles of N-linked glycans in the recognition of microbial lipopeptides and lipoproteins by TLR2.
Cell Microbiol 8(7):1199-209, 2006.
PMID: 16819971

Okada M, Okuno Y, Hashimoto S , Kita Y, Kanamaru N, Nishida Y, Tsunai Y, Inoue R, Nakatani H, Fukamizu R, Namie Y, Yamada J, Takao K, Asai R, Asaki R, Kase T, Takemoto Y, Yoshida S, Peiris JSM, Chen P-J, Yamamoto N, Nomura T, Ishida I, Morikawa S, Tashiro M, Sakatani M.:
Development of vaccines and passive immunotherapy against SARS coronavirus using mouse and SCID-PBL/hu mouse models.
Adv Exp Med Biol 581:561-6, 2006.
PMID: 17037598

Yoshida S & Watanabe H.:
Robust salivary gland-specific transgene expression in Anopheles stephensi mosquito.
Insect Mol Biol 15:403-10, 2006.
PMID: 16907827

Yoshida S, Tanaka T, Kita Y, Kuwayama S, Kanamaru N, Muraki Y, Hashimoto S, Inoue Y, Sakatani Y, Kobayashi E, Kaneda Y, Okada M.:
DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation.
Vaccine 24:1191-204, 2006.
PMID: 16216394

Kita Y, Tanaka T, Yoshida S. Ohara N, Kaneda Y, Kuwayama S, Muraki Y, Kanamaru N, Hashimoto S, Takai H, Okada C, Fukunaga Y, Sakaguchi Y, Furukawa I, Yamada K, Inoue Y, Takemoto Y, Naito M, Yamada T, Matsumoto M, McMurray DN, Cruz ECD, Tan EV, Abalos RM, Young LJ, Burgos JA, Gelber R, Skeiky Y, Reed S, Sakatani M, Okada M.:
Novel recombinant BCG and DNA-vaccination against tuberculosis in a cynomolgus monkey model.
Vaccine 23:2132-5, 2005.
PMID: 15755583

Okada M, Takemoto Y, Okuno Y, Hashimoto S, Yoshida S, Fukunaga Y, Tanaka T, Kita Y, Kuwayama S, Muraki Y, Kanamaru N, Takai H, Okada C, Sakaguchi Y, Furukawa I, Yamada K, Matsumoto M, Kase T, deMello DE, Peiris JSM, Chen P-J, Yamamoto N, Yoshinaga Y, Nomura T, Ishida I, Morikawa S, Tashiro M, Sakatani M.:
The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.
Vaccine 23:2269-72, 2005.
PMID: 15755609

Lee LF, Bacon LD, Yoshida S, Yanagida N, Zhang HM, Witter RL.:
The efficacy of recombinant fowlpox vaccine protection against Marek's disease: its dependence on chicken line and B haplotype.
Avian Dis 48:129-37, 2004.
PMID: 15077806

Yoshida S, Kondoh D, Arai E, Matsuoka H, Seki C, Tanaka T, Okada M, Ishii A.:
Baculovirus virions displaying Plasmodium berghei circumsporozoite protein protects mice against malaria sporozoite infection.
Virology 316: 161-70, 2003.
PMID: 14599800

Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S.:
Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus.
Avian Dis 47:549-58, 2003.
PMID: 14562881

Yoshida S, Kobayshi T, Matsuoka H, Seki C, Gosnell WL, Chang SP, Ishii A.:
T cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites.
Blood 101: 2300-2306, 2003.
PMID: 12411309

Wang J, Hirai M, Yoshida S, Arai M, Ishii A, Matsuoka H.:
Comparison of malaria parasite gametocyte activating factor in the salivary glands of five species of mosquito (Diptera: Culicidae).
Med Entomol Zool 53: 177-182, 2002.

Yoshida S., Ioka D, Matsuoka H, Endo H, Ishii A.:
Bacteria expressing single-chain immunotoxin inhibit malaria parasite development in mosquitoes.
Mol Biochem Parasitol 113: 89-96, 2001.
PMID: 11254957

Yoshida S, Fujisawa A, Tsuzaki Y, Saito S.:
Identification and expression of a Mycoplasma gallisepticum surface antigen recognized by a monoclonal antibody capable of inhibiting both growth and metabolism.
Infect Immun 68: 3186-3192, 2000.
PMID: 10816462

Yoshida S, Kashiwamura S, Hosoya Y, Luo E, Matsuoka H, Ishii A, Fujimura A. Kobayashi E.:
Direct immunization into the liver by gene gun protects against lethal challenge of Plasmodium berghei sporozoite.
Biochem Biophy Res Commun 271: 107-115, 2000.
PMID: 10777689

Luo E, Matsuoka H, Yoshida S, Iwai K, Arai M, Ishii A.:
Changes of salivary proteins during feeding and detection of salivary proteins in the midgut after feeding in a malaria vector mosquito, Anopheles stephensi (Diptera: Culicidae).
Med Entomol Zool 51: 13-20, 2000.

Wu P, Reed WM, Yoshida S, Sui D, Lee LF.:
Identification and characterization of glycoprotein H of MDV-1 GA strain.
Acta Virol 43: 152-158, 1999.
PMID: 10696437

Yoshida S, Matsuoka H, Luo E, Iwai K, Arai M, Sinden RE, Ishii A.:
A single-chain antibody fragment specific for the Plasmodium berghei ookinete protein Pbs21 confers transmission blockade in the mosquito midgut.
Mol Biochem Parasitol 104: 195-204,1999.
PMID: 10593175

Yoshida S, Lee L.F, Yanagida N, Nazerian K.:
Identification and characterization of a Marek's disease virus gene homologous to glycoprotein L of herpes simplex virus.
Virology 204: 414-419, 1994.
PMID: 8091671

Yoshida S, Lee LF, Yanagida N, Nazerian K.:
The glycoprotein B genes of Marek's disease virus serotype 2 and 3: Identification and expression by recombinant fowlpox viruses.
Virology 200: 484-493, 1994.
PMID: 8178437

Yoshida S, Lee LF, Yanagida N, Nazerian K.:
Mutational analysis of the proteolytic cleavage site of glycoprotein B (gB) of Marek's disease virus.
Gene 150: 303-306, 1994.
PMID: 7821796

Yanagida N., Yoshida S, Nazerian K, Lee LF.:
Nucleotide and predicted amino acid sequences of Marek's disease virus homologues of herpes simplex virus major tegument proteins.
J Gen Virol 74: 1837-1845, 1993.
PMID: 8397281