生体防御応答学研究室

Publication List 1995-2010 (partial list)

Laboratory of Molecular and Cellular Biochemistry,

Grad. Sch. Med. Sci., Kanazawa Univ.

Shiratsuchi, A., Shimizu, K., Watanabe, I., Hashimoto, Y., Kurokawa, K., Razanajatovo, I. M., Park, K. H., Park H. K., Lee, B. L., Sekimizu, K., and Nakanishi, Y. Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages. Immunololgy 129, 268-277 (2010)

Wu, Z., Ma, H., Kukita, T., Nakanishi, Y., and Nakanishi, H. Phosphatidylserine-containing liposoomes inhibit the differentiation of osteoclasts and trabecular bone loss. J. Immunol. 184, 3191-3201 (2010)

Kuraishi, T., Nakagawa, Y., Nagaosa, K., Hashimoto, Y., Ishimoto, T., Moki, T., Fujita, Y., Nakayama, H., Dohmae, N., Shiratsuchi, A., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki, T., and Nakanishi, Y. Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells. EMBO J. 28, 3668-3878 (2009)

Hashimoto, Y., Tabuchi, Y., Sakurai, K., Kutsuna, M., Kurokawa, K., Awasaki, T., Sekimizu, K., Nakanishi, Y., and Shiratsuchi, A. Identification of lipoteichoic acid as a ligand for Draper in the phagocytosis of Stapylococcus aureus by Drosophila hemocytes. J. Immunol. 183, 7451-7460 (2009)

Nagaosa, K., Nakashima, C., Kishimoto, A., and Nakanishi, Y. Immune response to bacteria in seminiferous epithelium. Reproduction 137, 879-888 (2009)

Osada, Y., Sunatani, T., Kim, I.-S., Nakanishi, Y., and Shiratsuchi, A. Signaling pathway involving GULP, MAPK, and Rac1 for SR-BI-induced phagocytosis of apoptotic cells. J. Biochem. 145, 387-394 (2009)

Shiratsuchi, A., Ichiki, M., Okamoto, Y., Ueda, N., Sugimoto, N., Takuwa, Y., and Nakanishi, Y. Inhibitory effct of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42. J. Biochem. 145, 43-50 (2009)

Shiratsuchi, A. (review) Study on the mechanism and role of phagocytic elimination of microbes and microbe-infected cells. J. Juzen Med. Soc. 118, 9-12 (2009)

Nakanishi, Y., Henson, P. M., and Shiratsuchi, A. (book chapter) Pattern recognition in phagocytic clearance of altered self. In: Target Pattern Recognition in Innate Immunity, chapter 11, U. Kishore (ed.), Landes Bioceicned (2009)

Kurokawa, K., Lee, H., Rho, K.-B., Asanuma, M., Kim, Y.S., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, H.J., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., and Lee, B.-L. The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for the Toll-like receptor 2. J. Biol. Chem. 284, 8406-8411 (2009)

Shiratsuchi, A., Watanabe, I., Ju, J.-S., Lee, B.-L., and Nakanishi, Y. Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Eschericha coli. Immunology 124, 575-583 (2008)

Nagaosa, K., Aikoshi, I., Hasegawa, Y., and Nakanishi, Y. Activator protein 1-mediated expression of monocyte chemoattractant protein 1 in cultured rat luteal cells. Mol. Reprod. Dev. 75, 1077-1084 (2008)

Shiratsuchi, A., Watanabe, I., Yoshida, H., and Nakanishi, Y. Involvment of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. Immunol. Cell Biol. 86, 179-184 (2008)

Nakanishi, Y., Hashimoto, Y., Takizawa, T., and Shiratsuchi, A. (review) Mechanisms and consequences of phagocytosis of influenza virus-infected cells. Anti-Inflammatory & Anti-Allegy Agents in Medicinal Chemistry, 7, 97-100 (2008)

Watanabe, I., Ichiki, M., Shiratsuchi, A., and Nakanishi, Y. Tlr2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity. J. Immunol. 178, 4917-4925 (2007) Picked up in the “IN THIS ISSUE”

Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., and Nakanishi, Y. Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. J. Immunol. 178, 2448-2457 (2007) Selected by “Faculty of 1000 Biology, Immunology Section”

Kuraishi, T., Manaka, J., Kono, M., Ishii, H., Yamamoto, N., Koizumi, K., Shiratsuchi, A., Lee, B. L., Higashida, H., and Nakanishi, Y. Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. Exp. Cell Res. 313, 500-510 (2007)

Nagaosa, K.*, Kishimoto, A.*, Kizu, R., Nakagawa, A. Shiratsuchi, A., and Nakanishi, Y. Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice. Reproduction 133, 21-27 (2007) *equally contributed

Kakishima, K., Shiratsuchi, A., Taoka, A., Nakanishi, Y., and Fukumori, Y. Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages. Biochem. Biophys. Res. Commun. 355, 587-591 (2007)

Nakanishi, Y., and Shiratsuchi, A. (review) Mechanisms and roles of phagocytosis in Drosophila and Caenorhabditis elegans. Invert. Surviv. J. 3, 89-96 (2006)

Osada, Y., Shiratsuchi, A., and Nakanishi, Y. Involvement of mitogen-activated protein kinases in class B scavenger receptor type I-induced phagocytosis of apoptotic cells. Exp. Cell Res. 312, 1820-1830 (2006)

Awasaki, T., Tatsumi, R., Takahashi, K., Arai, K., Nakanishi, Y., Ueda, R., and Ito K. Essential role of the apoptotic cell engulfment genes draper and ced-6 in developmentally programmed axon pruning during Drosophila metamorphosis. Neuron 50, 855-867 (2006)

Bayarsaikhan, M.*, Shiratsuchi, A.*, Gantulga, D., Nakanishi, Y., and Yoshioka, K. Selective expression of the scaffold protein JSAP1 in spermatogonia and spermatocytes. Reproduction 131, 711-719 (2006)　*equally contributed

Zhang, J., Fujii, S., Wu, Z., Hashioka, S., Tanaka, Y., Shiratsuchi, A., Nakanishi, Y., and Nakanishi, H. Involvement of COX-1 and up-regtulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia. J. Neuroimmunol. 172, 112-120 (2006)

Watanabe, Y., Hashimoto , Y., Shiratsuchi, A., Takizawa, T., and Nakanishi, Y. Augmentation of fatality of influenza in mice by inhibition of phagocytosis. Biochem. Biophys. Res. Commun. 337, 881-886 (2005)

Nakai, Y., Shiratsuchi, A., Manaka, J., Nakayama, H., Takio, K., Zhang, J.-T., Suganuma, T., and Nakanishi, Y. Externalization and recognition by macrophages of large subunit of eukaryotic translation initiation factor 3 in apoptotic cells. Exp. Cell Res. 309, 137-148 (2005)

Nakagawa, A., Shiratsuchi, A., Tsuda, K., and Nakanishi, Y. In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells. Mol. Reprod. Dev. 71, 166-177 (2005)

Nakai, Y., Nomura, Y., Sato, T., Shiratsuchi, A., and Nakanishi, Y. Isolation of a Drosophila gene coding for a protein containing a novel phosphatidylserine-binding motif. J. Biochem. 137, 593-599 (2005)

Kato, S., Shiratsuchi, A., Nagaosa, K., and Nakanishi, Y. Phosphatidylserine- and integrin-mediated phagocytosis of apoptotic luteal cells by macrophages of the rat. Dev. Growth Differ. 47, 153-161 (2005)

Ishii, H., Mori, T., Shiratsuchi, A., Nakai, Y., Shimada, Y., Ohno-Iwashita, Y., and Nakanishi, Y. Distinct localization of lipid rafts and externalized phosphatidylserine at the surface of apoptotic cells. Biochem. Biophys. Res. Commun. 327, 94-99 (2005)

Kido, T., Arata, S., Suzuki, R., Hosono, T., Nakanishi, Y., Miyazaki, J., Saito, I., Kuroki, T., and Shioda, S. The testicular fatty acid binding protein PERF15 regulates the fate of germ cells in PERF15 transgenic mice. Dev. Growth Differ. 47, 15-24 (2005)

Tsuda, K., Amano, A., Umebayashi, K., Inaba, H., Nakagawa, I., Nakanishi, Y., and Yoshimori, T. Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial vesicle. Cell Struct. Funct. 30, 81-91 (2005)

Watanabe, Y., Shiratsuchi, A., Shimizu, K., Takizawa, T., and Nakanishi, Y. Stimulation of phagocytosis of influenza virus-infected cells through surface desialylation of macrophages by viral neuraminidase. Microbiol. Immunol. 48, 875-881 (2004)

Manaka, J., Kuraishi, T., Shiratsuchi, A., Nakai, Y., Higashida, H., Henson, P., and Nakanishi, Y. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. J. Biol. Chem. 279, 48466-48476 (2004)

Nakanishi, Y. and Shiratsuchi, A. (review) Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: mechanisms and consequences. Biol. Pharm. Bull. 27, 13-16 (2004)

Nakagawa, A., Nagaosa, K., Hirose, T., Tsuda, K., Hasegawa, K., Shiratsuchi, A., and Nakanishi, Y. Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat. Dev. Growth Differ. 46, 283-298 (2004)

Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., and Nakanishi, Y. Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages. J. Immunol. 172, 2039-2047 (2004)

Nakamoto, T., Shiratsuchi, A., Oda, H., Matsumura, T., Ichikawa, M., Saito, T., Seo, S., Maki, K., Asai, T., Suzuki, T., Yamagata, T., Aizawa, S., Noda, M., Nakanishi, Y., and Hirai, H. Impairment of spermatogenesis and male fertility in CIZ/Nmp4-disrupted mice. Genes Cells 9, 575-589 (2004)

Takizawa, T., Tatematsu, C., Watanabe, K., Kato, K., and Nakanishi, Y. Cleavage of calnexin caused by apoptotic stimuli: an implication for the regulation of apoptosis. J. Biochem. 136, 399-405 (2004)

Frasch, S. C., Henson, P. M., Nagaosa, K., Fessler, M. B., Borregaard, N., and Bratton, D. Phospholipid flip-flop and phospholipid scramblase (PLSCR1) co-localize to uropod rafts in fMLP stimulated neutrophils. J. Biol. Chem. 279, 17625-17633 (2004)

Nagaosa, K., Shiratsuchi, A., and Nakanishi, Y. Concomitant induction of apoptosis and expression of monocyte chemoattractant protein 1 in cultured rat luteal cells by nuclear factor kB and oxidative stress. Dev. Growth Differ. 45, 351-359 (2003)

Shiratsuchi, A., Mori, T., Takahashi, Y., Sakai, K., and Nakanishi, Y. A presumed human nuclear autoantigen that translocates to plasma membrane blebs during apoptosis. J. Biochem. 133, 211-218 (2003)

Nagaosa, K., Shiratsuchi, A., and Nakanishi, Y. Determination of cell type specificity and estrous cycle dependency of monocyte chemoattractant protein-1 expression in corpora lutea of normally cycling rats in relation to apoptosis and monocyte/macrophage accumulation. Biol. Reprod. 67, 1502-1508 (2002)

Shiratsuchi, A., Mori, T., and Nakanishi, Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells. J. Biochem. 132, 381-386 (2002)

Kawasaki, Y., Nakagawa, A., Nagaosa, K., Shiratsuchi, A., and Nakanishi, Y. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells. J. Biol. Chem. 277, 27559-27566 (2002)

Nakanishi, Y., Shiratsuchi, A., and Takizawa, T. (book chapter) Mechanism and physiological role of apoptosis induction in influenza virus-infected cells. In: Recent Advances in Influenza Virus Research, pp. 55-61, Y. Hayase (ed), Research Signpost (2002)

Maeda, Y., Shiratsuchi, A., Namiki, M., and Nakanishi, Y. Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death Differ. 9, 742-749 (2002)

Watanabe, Y., Shiratsuchi, A., Shimizu, K., Takizawa, T., and Nakanishi, Y. Role of phosphatidylserine exposure and sugar chain desialylation at the surface of influenza virus-infected cells in efficient phagocytosis by macrophages. J. Biol. Chem. 277, 18222-18228 (2002)

Nishida, J., Shiratsuchi, A., Nadano, D., Sato, T., and Nakanishi, Y. Structural change of ribosomes during apoptosis: degradation and tra nslocation of ribosomal proteins in doxorubicin-treated Jurkat cells. J. Biochem. 131, 485-493 (2002)

Takizawa, T., Tatematsu, C., and Nakanishi, Y. Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1: implications for apoptosis signaling pathways. Eur. J. Biochem. 269, 6126-6132 (2002)

Fujii, C., Shiratsuchi, A., Manaka, J., Yonehara, S., and Nakanishi, Y. Difference in the way of macrophage recognition of target cells depending on their apoptotic states. Cell Death Differ. 8, 1113-1122 (2001)

Stephanou, A., Scarabelli, T. M., Brar, B. K., Nakanishi, Y., Matsumura, M., Knight, R. A., and Latchman, D. S. Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. J. Biol. Chem. 276, 28340-28347 (2001)

Koji, T., Hishikawa, Y., Ando, H., Nakanishi, Y., and Kobayashi, N. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biol. Reprod. 64, 946-954 (2001)

Shiratsuchi, A., Kaido, M., Takizawa, T., and Nakanishi, Y. Phosphatidylserine-mediated phagocytosis of influenza A virus-infected cells by mouse peritoneal macrophages. J. Virol. 74, 9240-9244 (2000)

Ando, H., Haruna, Y., Suzuki, M., Yamada, S., Okabe, M., and Nakanishi, Y. Ectopic activation of the transcription promoter for the testis-specific mouse Pgk-2 gene on elimination of a cis-acting upstream DNA region. Dev. Growth Differ. 42, 385-393 (2000)

Ando, H., Haruna, Y., Miyazaki, J., Okabe, M., and Nakanishi, Y. Spermatocyte-specific gene excision by targeted expression of Cre recombinase. Biochem. Biophys. Res. Commun. 272, 125-128 (2000)

Fujimoto, I., Pan, J., Takizawa, T., and Nakanishi, Y. Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages. J. Virol. 74, 3399-3403 (2000)　

Shiratsuchi, A., and Nakanishi, Y. Phosphatidylserine-mediated phagocytosis of anticancer drug-treated cells by macrophages. J. Biochem. 126, 1101-1106 (1999)

Maeda, T., Nishida, J., and Nakanishi, Y. Expression pattern, subcellular localization and structure-function relationship of rat Tpx-1, a spermatogenic cell adhesion molecule responsible for association with Sertoli cells. Dev. Growth Differ. 41, 715-722 (1999)

Shiratsuchi, A., Kawasaki, Y., Ikemoto, M., Arai, H., and Nakanishi, Y. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. J. Biol. Chem. 274, 5901-5908 (1999)

Halleck, M. S., Lawler Jr., J. F., Blackshaw, S., Gao, L., Nagarajan, P., Hacker, C., Pyle, S., Newman, J. T., Nakanishi, Y., Ando, H., Weinstock, D., Williamson, P., and Schlegel, R. A. Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics 1, 139-150 (1999)

Takizawa, T., Tatematsu, C., Ohashi, K., and Nakanishi, Y. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol. Immunol. 43, 245-252 (1999)

Takizawa, T., Tatematsu, C., and Nakanishi Y. Double-stranded RNA-activated protein kinase (PKR) fused to green fluorescent protein induces apoptosis in human embryonic kidney cells: Possible role in Fas signaling pathway. J. Biochem. 125, 391-398 (1999)

Maeda, T., Sakashita, M., Ohba, Y., and Nakanishi, Y. Molecular cloning of the rat Tpx-1 responsible for the interaction between spermatogenic and Sertoli cells. Biochem. Biophys. Res. Commun. 248, 140-146 (1998)

Shiratsuchi, A., Osada, S., Kanazawa, S., and Nakanishi, Y. Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages. Biochem. Biophys. Res. Commun. 246, 549-555 (1998)

Li, X., Sumi, T., Matsukawa, T., Nakanishi, Y., and Ohba, Y. Thyroid hormone, all-trans retinoic acid, and 9-cis retinoic acid function as negative modulators of the effect of glucocorticoid on induction of a1-acid glycoprotein mRNA in RLN-10 cells. Biochem. Mol. Biol. Int. 45, 1-10 (1998)

Fujimoto, I., Takizawa, T., Ohba, Y., and Nakanishi, Y. Co-expression of Fas and Fas-ligand on the surface of influenza virus-infected cells. Cell Death Differ. 5, 426-431 (1998)

Nogae, S., Miyazaki, M., Kobayashi, N., Saito, T., Abe, K., Saito, H., Nakane, P. K., Nakanishi, Y., and Koji, T. Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas. J. Am. Soc. Nephrol. 9, 620-631 (1998)　

Tokumura, K., Nagaosa, K., Ohta, Y., and Matsushima, R. Temperature-dependent tautomer fluorescence spectra of 3ﾕ,4ﾕ,-benzo-2ﾕ-hydroxychalcone: direct evidence for photoenolization followed by Z ｮ_E isomerization in the singlet manifold. Chem. Phys. Lett. 295, 516-524 (1998)

Shiratsuchi, A., Umeda, M., Ohba, Y., and Nakanishi, Y. Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat. J. Biol. Chem. 272, 2354-2358 (1997)

Mizuno, K., Shiratsuchi, A., Masamune, Y., and Nakanishi, Y. The role of Sertoli cells in the differentiation and exclusion of rat testicular germ cells in primary culture. Cell Death Differ. 3, 119-123 (1996)

Takizawa, T., Ohashi, K., and Nakanishi, Y. Possible involvement of double-stranded RNA-activated protein kinase (PKR) in the cell death by influenza virus infection. J. Virol. 70, 8128-8132 (1996)

Wada, N., Matsumura, M., Ohba, Y., Kobayashi, N., Takizawa, T., and Nakanishi, Y. Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection. J. Biol. Chem. 270, 18007-18012 (1995)

Takizawa, T., Fukuda, R., Miyawaki, T., Ohashi, K., and Nakanishi, Y. Activation of the apoptotic Fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon. Virology 209, 288-296 (1995)

Okazaki, M., Hino, K., Fujii, K., Hanada, H., Nakanishi, Y., Kanazawa, S., Kobayashi, N., and Okita, K. Immunohistochemical study of Fas antigen in liver of patients with chronic hepatitis or autoimmune liver disease. Int. J. Hepat. Commun. 3, 285-289 (1995)

Monesi, N., Fernandez, M. A., Fontes, A. M., Basso Jr., L. R., Nakanishi, Y., Baron, B., Buttin, G., and Paco-Larson, M. L. Molecular characterization of an 18 kb segment of DNA puff C4 of Bradysia Hygida (Diptera, Sciaridae) Chromosoma 103, 715-724 (1995)