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For the novel therapeutic agents, for the patients.

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Faculty of Pharmacy, Kanazawa Univ, Kakuma-machi, Kanazawa 920-1192, Japan 

分子を利用し薬物治療を目指す

We are performing research to identify novel molecular targets in the body which can be applied to develop therapeutic agents. Our research is principally based on pharmacology and pharmacokinetics. The ultimate goal of our research is solely to controbute to the development of pharmacotherapeutics for the patients and to overcome variou diseases.

Previous Information


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  • December 30, 2019
    Original paper mainly performed by collaborators was accepted.
    Takahashi Y, Zhou Y, Miyamoto T, Higashi H, Nakamichi N, Takeda Y, Kato Y, Korchev Y, Fukuma T. High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons. Anal Chem 92(2):2159-2167, 2020.

  • December 27, 2019
    Original paper was accepted:
    Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y, Kanamori T, Kato Y. Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system. Lab on a Chip 20(3):537-547, 2020.

  • December 9-12, 2019
    Mr. Takumi Kawanishi (D1) received Best Oral Presentation Award, and Ms. Karin Araya (M2) recieved Best Poster Award in 2019 JSSX meeting (Tsukuba, Japan).

  • November 23, 2019
    Review paper based on collaboration study was accepted:
    Mizutani S, Matsumoto K, Kato Y, Mizutani E, Mizutani H, Iwase A, Shibata K.New insights into human endometrial aminopeptidases in both implantation and menstruation. Biochim Biophys Acta 1868(2):140332, 2020.

  • August 30, 2019
    Original paper was accepted:
    Hashimoto N, Nakamichi N, Nanmo H, Kimura K, Masuo Y, Sakai Y, Schinkel AH, Sato S, Soga T, Kato Y. Metabolome analysis reveals dermal histamine accumulation in murine dermatitis provoked by genetic deletion of P-glycoprotein and breast cancer resistance protein. Pharm Res 36(11): 158, 2019.

  • August 6, 2019
    Original paper was accepted:
    Taguchi T, Masuo Y, Sakai Y, Kato Y. Short-lasting inhibition of hepatic uptake transporter OATP1B1 by tyrosine kinase inhibitor pazopanib. Drug Metab Pharmacokinet 34(6):372-379, 2019.

  • June 14, 2019
    Original paper was accepted:
    Nakamichi N, Matsumoto Y, Kawanishi T, Ishimoto T, Masuo Y, Horikawa M, Kato Y. Maturational characterization of mouse cortical neurons three-dimensionally cultured in functional polymer FP001-containing medium. Biol Pharm Bull 42(9): 1545-1553, 2019.

  • May 12, 2019
    Original paper was accepted:
    Kawanishi T, Arakawa H, Masuo Y, Nakamichi N, Kato Y. Bile duct obstruction leads to increased intestinal expression of breast cancer resistance protein with reduced gastrointestinal absorption of imatinib. J Pharm Sci 108(9): 3130-3137, 2019.

  • March 22, 2019
    Graduation Ceremony

  • March 1, 2019
    Dr. Takahiro Ishimoto has joined our laboratory as a research associate.

  • February 26, 2019
    Farewel Party for graduates

  • January 18, 2019
    Original paper was accepted:
    Al-Shammari AH, Masuo Y, Fujita K, Yoshikawa Y, Nakamichi N, Kubota Y, Sasaki Y, Kato Y. Influx and efflux transporters contribute to the increased dermal exposure to active metabolite of regorafenib after repeated oral administration. J Pharm Sci 108(6): 2173-2179, 2019.

  • January 11, 2019
    New comers (3rd year students, School of Pharmacy) joined our laboratory.

  • January 10, 2019
    Original paper was accepted:
    Hydrolyzed salmon milt extract enhances object recognition and location memory through an increase in hippocampal cytidine nucleoside levels in normal mice. Nakamichi N, Nakao S, Masuo Y, Koike A, Matsumura N, Nishiyama M, Al-Shammari AH, Sekiguchi H, Sutoh K, Usumi K, Kato Y. J Med Food 22(4): 408-415, 2019.

  • October19, 2018
    Original paper was accepted:
    Ishimoto T, Masuo Y, Kato Y, and Nakamichi N. Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. Cellular Signalling 53: 269-280, 2019.

  • 2018/10/1
    A new comer (in Graduate School of Pharmaceutical Sciences) joined our laboratory (Ms. Rina Agustin from Hasanuddin University in Indonesia).

  • September 19, 2018
    Original paper was accepted:
    Masuo Y, Ohba Y, Yamada K, Al-Shammari AH, Seba N, Nakamichi N, Ogihara T, Kunishima M, Kato Y. Combination metabolomics approach for identifying endogenous substrates of carnitine/organic cation transporter OCTN1. Pharm Res 35(11), in press 2018.

  • May 11, 2018
    Mr. Sun Chang Chneg (China Pharmaceutical University) stays in our laboratory as a visiting student.

  • February 26, 2018
    Farewel Party for Drs. Nakamichi and Ishimoto, and graduates

  • February 20, 2018
    Graduation Presentation by M2

  • February 16, 2018
    Graduation Presentation by B4 in School of Pharmaceutical Sciences.

  • February 8, 2018
    Original paper was accepted:
    Futatsugi A, Toshimoto K, Yoshikado T, Sugiyama Y, Kato Y. Evaluation of alteration in hepatic and intestinal BCRP function in vivo due to ABCG2 c.421C>A polymorphism based on PBPK analysis of rosuvastatin. Drug Metab Dispos 46(5): 749-757, 2018.

  • January 12, 2018
    New comers (3rd year students, School of Pharmacy) joined our laboratory.

  • December 15, 2017
    New comers (3rd year students, School of Pharmaceutical Sciences) joined our laboratory.

  • November 27, 2017
    Graduation Presentation by B6

  • November 26, 2017
    Ms. Koike (B4) and Mr. Shimada (B4) performed presentation in the 129th Annual Meeting of Hokuriku Branch in the Pharmaceutical Society of Japan (Kanazawa, Japan).

  • October 27, 2017      
    Original paper was accepted:
    Ellawatty WEA, Masuo Y, Fujita K, Yamazaki E, Ishida H, Arakawa H, Nakamichi N, Abdelwahed R, Sasaki Y, Kato Y. Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Drug Metab Dispos 46(1): 33-40, 2018.

  • October 26-27, 2017
    Dr. Masuo and Mr. Kawanishi (M1) performed presentation in the 39th Symposium on Interaction of Biomembranes and Drugs (Kanazawa, Japan).


  • July 5, 2017      
    Original paper was accepted:
    Ishimoto T, Nakamichi N, Nishijima H, Masuo Y, Kato Y. Carnitine/organic
    cation transporter OCTN1 negatively regulates activation in murine cultured
    microglial cells. Neurochem Res 43(1): 107-119, 2018.

  • May 11-13, 2017
    Dr. Masuo and Mr. Kawanishii (M1) performed presentation in the 32th Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan (Omiya, Japan). Dr. Masuo winned the best presentation prize.

  • April 24, 2017      
    Original paper was accepted:
    Fujita K, Masuo Y, Yamazaki E, Shibutani T, Kubota Y, Nakamichi N, Sasaki Y, Kato Y. Involvement of the transporters P-gp and BCRP in dermal distribution of the multi-kinase inhibitor regorafenib and its active metabolites. J Pharm Sci 106(9): 2632-2641, 2017.

  • April 17, 2017
    Welcome Party for New Collaborators

  • March 24-27, 2017
    Ms. Komori (B4) performed presentation in the 137th Annual Meeting of the Pharmaceutical Society of Japan (Sendai, Japan).

  • March 13, 2017
    Farewel Party for graduates

  • March 4, 2017
    Original paper was accepted:
    Masuo Y, Nagamori S, Hasegawa A, Hayashi K, Isozumi N, Nakamichi N, Kanai Y, Kato Y. Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans. Pharm Res 34(6): 1233-1243, 2017.

  • February 23, 2017
    Original paper was accepted:
    Hashimoto N, Nakamichi N, Yamazaki E, Oikawa M, Masuo Y, Schinkel AH, Kato Y. P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids. Int J Pharm 521(1-2):365-373, 2017.

  • February 21-22, 2017
    Graduation Presentation by M2

  • February 17, 2017
    Graduation Presentation by B4 in School of Pharmaceutical Sciences.

  • January 13, 2017
    New comers (3rd year students, School of Pharmacy) joined our laboratory.

  • December 26, 2016
    Laboratory Cleaning and Year-End Party

  • December 16, 2016
    New comers (3rd year students, School of Pharmaceutical Sciences) joined our laboratory.

  • November 29, 2016
    Graduation Presentation by B6

  • November 27, 2016
    Mr. Kawanishi (B4) will perform presentation in the 128th Annual Meeting of Hokuriku Branch in the Pharmaceutical Society of Japan (Kanazawa, Japan).

  • November 17-18, 2016
    Dr. Nakamichi and Mr. Ishimoto (D3) will perform presentation in the 38th Symposium on Interaction of Biomembranes and Drugs (Nagoya, Japan).

  • October 13-15, 2016
    Dr. Masuo, Mr. Taguchi (D3), Ms. Ohba (M2), Ms. Futatsugi (M2), Ms. Ainaka (M1), Ms. Hasegawa (B5), Ms. Yamazaki (B5) and Ms. Seba (B4) performed presentation in 31th Annual Meeting of JSSX (Matsumoto, Japan).

  • July 26, 2016
    Original paper was accepted:
    Nakamichi N, Ishimoto T, Yamauchi Y, Masuo Y, Kato Y. Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity. Biol Pharm Bull 39(10): 1638-1645, 2016.

  • July 3-5, 2016
    Dr. Nakamichi and Mr. Ishimoto (D3) performed presentation in the CINP 30th World Congress of Neuropsychopharmacology (Seoul).

  • April 30, 2016
    Original paper was accepted:
    Futatsugi A, Masuo Y, Kawabata S, Nakamichi N, Kato Y. L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides. J Pharm Pharmacol 68(9): 1160-1169, 2016.

  • April 20, 2016
    Original paper was accepted:
    Taguchi T, Masuo Y, Kogi T, Nakamichi N, Kato Y. Characterization of long-lasting Oatp inhibition by typical inhibitor cyclosporine A and in vitro-in vivo discrepancy in its drug interaction potential in rats. J Pharm Sci 105(7):2231-2239, 2016.

  • April 19, 2016
    Welcome Party for New Collaborators

  • March 26-29, 2016
    Ms. Nishijima (B5), Takeda (B4) and Hasegawa (B4) performed presentation in The 136th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama, Japan).

  • March 22, 2016
    Graduation Ceremony

  • March 17, 2016
    Original paper was accepted (collaboration study with Drs Sekiguchi, Sutoh and Usumi in Life Science Institute Co. Ltd.):
    Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y. Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. Brain and Behavior e00477, 2016.

  • March 15, 2016
    Farewel Party for graduates

  • March 12, 2016
    Original paper mainly done by our collaborators was accepted:
    Ben Said M, Grati M, Ishimoto T, Zou B, Chakchouk I, Ma Q, Yao Q, Hammami B, Yan D, Mittal R, Nakamichi N, Ghorbel A, Neng L, Tekin M, Shi XR, Kato Y, Masmoudi S, Lu Z, Hmani M, Liu X.A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60. Hum Genet 135(5): 513-524, 2016.

  • March 9-11, 2016
    Mr. Ishimoto (D2) and Ms. Nishiyama (M2) performed presentation in The 89th Annual Meeting of The Japanese Pharmacological Society (Yokohama, Japan).

  • February 22-23, 2016
    Graduation Presentation by M2

  • February 12, 2016
    Graduation Presentation by B4 in School of Pharmaceutical Sciences.

  • February 1, 2016
    Dr. Hiroshi Arakawa joined our laboratory as a new Research Associate.

  • January 19, 2016
    Special Lecture of Dr. Hiroo Ishida (Showa Univ)

  • January 8, 2016
    New comers (3rd year students, School of Pharmacy) joined our laboratory.

  • December 25, 2015
    Laboratory Cleaning and Farewel Party for Ms. Lica Ishida.

  • December 15, 2015
    Original paper was accepted (collaboration study with Drs Sekiguchi, Sutoh and Usumi in Life Science Institute Co. Ltd.):
    Tang Y, Masuo Y, Sakai Y, Wakayama T, Sugiura T, Harada R, Futatsugi A, Komura T, Nakamichi N, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kaneko S, Kato Y. Localizatoin of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis. J Pharm Sci 105(5): 1779-1789, 2016

  • December 11, 2015
    New comers (3rd year students, School of Pharmaceutical Sciences) joined our laboratory.

  • November 30, 2015
    Graduation Presentation by B6

  • November 12-14, 2015
    Mr. Taguchi (D2), Ms. Nishiyama (M2), Ms. Ohba (M1) and Ms. Futatsugi (M1) performed presentation in 30th Annual Meeting of JSSX (Tokyo, Japan).

  • September 4, 2015
    Mr. Mitamura (M1) performed presentation in 10th Annual Meeting in Gene and Nutritional Science Association (Kitahiroshima, Japan).

  • August 26, 2015
    Original paper was accepted (collaboration study with Drs Ken-ichi Fujita and Yasutsuna Sasaki in Showa University, Profs Munetaka Kunishima and Masanori Kitamura in this Faculty):
    Fujita K, Masuo Y, Okumura H, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Akiyama Y, Kitamura M, Kunishima M, Sasaki Y, Kato Y. Increased plasma concentrations of unbound SN-38, the active metabolite of irinotecan, in cancer patients with severe renal failure. Pharm Res 33(2): 269-282, 2016.

  • July 7, 2015
    Original paper mainly done by our collaborators was accepted:
    Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae E, Mohney R, Stirdivant SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A, Kim SJ. Dipeptide species regulate nutrient signalling essential for the maintenance of chronic myelogenous leukaemia stem cells. Nature Commun 6: 8039, 2015.

  • March 25-28, 2015
    Prof Nakamichi and Mr. Shibutani (B5) performed presentation in The 135th Annual Meeting of the Pharmaceutical Society of Japan (Kobe, Japan).

  • March 18-20, 2015
    Prof Nakamichi performed presentation in The 88th Annual Meeting of The Japanese Pharmacological Society (Nagoya, Japan).

  • February 23, 2015
    Original paper was accepted:
    Shimizu T, Kijima A, Masuo Y, Ishimoto T, Sugiura T, Takahashi S, Nakamichi N and Kato Y. Gene ablation of carnitine/organic cation transporter 1 reduces gastrointestinal absorption of 5-aminosalicylate in mice. Biol Pharm Bull, in press.

  • February 20, 2015
    Presentation of Graduation Theses (M2)

  • 2015/2/17
    Origianl paper was accepted:
    Shimizu T, Masuo Y, Takahashi S, Nakamichi N and Kato Y. Organic Cation Transporter Octn1-mediated Uptake of Food-derived Antioxidant Ergothioneine into Infiltrating Macrophages during Intestinal Inflammation in Mice.
    Drug Metab Pharmacokinet, in press.

  • February 12, 2015
    Presentation of Graduation Theses (B4)

  • January 20, 2015
    New comers (3rd year students, School of Pharmacy) joined our laboratory.

  • December 26, 2014
    Laboratory Cleaning and Year-End Party

  • December 11, 2014
    New comers (3rd year students, School of Pharmaceutical Sciences) joined our laboratory.

  • November 21, 2014
    Mr. Kogi (M1) performed presentation in The 36th Symposium on Interaction of Biomembranes and Drugs (Tokushima, Japan)

  • September 30, 2014 Mr. Kazuya Takeuchi graduated our laboratory and got Ph.D.

  • July, 2014 Open for Graduate Schools
    Master Degree (for Graduates from School of Pharmaceutical Sciences)
    Doctor Degree (for Graduates from School of Pharmaceutical Sciences)
    Doctor Degree (for Graduates from School of Pharmacy)

  • May 20, 2014
    Original paper was accepted (collaboration with Profs Masahiro Iwaki and Atsushi Kawase in Kinki Univ):
    Kawase A, Norikane S, Okada A, Adachi M, Kato Y, Iwaki M. Distinct Alterations in ABC Transporter Expression in Liver, Kidney, Small Intestine, and Brain in Adjuvant-induced Arthritic Rats. J Pharm Sci 103: 2556-2564, 2014.

  • May 6, 2014
    Original paper was accepted (collaboration with Prof. Kunio Matsumoto in Cancer Research Institute of Kanazawa Univ and Kringle Pharma, Inc):
    Adachi E, Hirose-Sugiura T, Kato Y, Ikebuchi F, Yamashita A, Abe T, Fukuta K, Adachi K and Matsumoto K. Pharmacokinetics and pharmacodynamics following intravenous administration of recombinant human hepatocyte growth factor in rats with renal injury. Pharmacology 94: 190-197, 2014.

  • April 9, 2014
    Welcome party for New comers (4th year students)

  • March 27-30, 2014
    Prof. Nakamichi performed presentation in The 134th Annual Meeting of the Pharmaceutical Society of Japan (Kumamoto, Japan)

  • March 19-21, 2014
    Prof. Nakamichi and Mr. Ishimoto (M2) performed presentation in The 87th Annual Meeting of The Japanese Pharmacological Society (Sendai, Japan)

  • March 14, 2014
    Farewell party for graduates

  • January 22, 2014
    Original paper was accepted:
    IshimotoT, Nakamichi N, Hosotani H, Masuo Y, Sugiura T and Kato Y. Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons. PLoS One 9: e89434, 2014.

  • January 18, 2014
    Original paper was accepted (collaboration study with Nissan Chemical Industries, LTD):
    Takeuchi K, Sugiura T, Matsubara K, Sato R, Shimizu T, Masuo Y, Horikawa M, Nakamichi N, Ishiwata N and Kato Y. Interaction of novel platelet-increasing agent eltrombopag with rosuvastatin via breast cancer resistance protein in human. Drug Metab Dispos 42: 726-734, 2014.

  • December 11, 2013
    New comers (3rd year students, School of Pharmaceutical Sciences) joined our laboratory.

  • July 19, 2013
    We organized Pharmacy Faculty Symposium 2013 in Kanazawa University

  • July 3, 2013
    Original paper was accepted (collaboration study with Drs Ken-ichi Fujita and Yasutsuna Sasaki in Showa University):
    Fujita K, Sugiura T, Okumura H, Umeda S, Nakamichi N, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Sasaki Y and Kato Y. Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans. Pharm Res, in press.

  • April 19, 2013
    Original paper was accepted:
    Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto K, Tsuji A and Kato Y. Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. J Pharm Sci 102: 3407-3417, 2013.

  • April 10, 2013
    Welcome party for Dr. Masuo was held.

  • April 1, 2013
    Dr. Yusuke Masuo joined our laboratory as a new Research Associate

  • December 26, 2012
    Farewell party for Dr. Tomoko Sugiura

  • December 12, 2012
    4 New comers joined our laboratory.

  • Decembedr 11, 2012
    Presentation of graduation study by 6th grade undergraduate students

  • December 5, 2012
    Original paper was accepted (collaboration study with Prof Toshiharu Horie's group
    in Chiba Univ)
    :
    Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T. Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria.Toxicol Sci 132: 32-42, 2013.

  • November 20-22, 2012
    Three members performed presentations in 27th JSSX Meeting (Chiba, Japan)

  • November 14-15, 2012
    Dr. Sugiura performed presentation in 34th PSJ Biological membrane Symposium (Kyoto, Japan)

  • October 14-18, 2012
    Two members performed poster presentations in 18th North American Regional ISSX Meeting (Dallas, Texas, USA).

  • October 13, 2012
    Original paper was accepted:
    Hashimoto N, Nakamichi N, Uwafuji S, Yoshida K, Sugiura T, Tsuji A, Kato Y. ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate. J Control Rel 165: 54-61, 2013.

  • September 19, 2012
    Original paper was accepted:
    Sugiura T, Takahashi S, Sano K, Abe T, Fukuta K, Adachi K, Nakamura T, Matsumoto K, Nakamichi N, Kato Y. Pharmacokinetic modeling of hepatocyte growth factor in
    experimental animals and humans. J Pharm Sci 102: 237-249, 2013.

  • September 15-16, 2012
    One member performed poster presentation in International Symposium on Epithelial Barrier and Transport 2012 (Kusatsu, Japan).

  • September 15, 2012
    Mr. Naoto Hashimoto(from Maruho CO. Ltd)has graduated our laboratory.

  • August 27, 2012
    Original paper was accepted:
    Nakamichi N, Taguchi T, Hosotani H, Wakayama T, Shimizu T, Sugiura T, Iseki S, Kato Y. Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation. Neurochem Int 61: 1121-1132, 2012.



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Updated : April 2, 2017
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Laboratory of Molecular Pharmacotherapeuticsビルダークリニック

Faculty of Pharmcy,
Kanazawa University,
Kakuma-machi,
Kanazawa 920-1102, Japan
bunyaku@p.kanazawa-u.ac.jp





金沢大学薬学類・ 創薬科学類へリンク




金沢大学薬学類・ 創薬科学類へリンク