2017Posted by admin

 
Novel Alkylating Reagents Designed by the Characteristics of 1,3,5-Triazines
Munetaka Kunishima, Kohei Yamada, Hikaru Fujita, and Masanori Kitamura
Journal of Synthetic Organic Chemistry, Japan
75 (10) pp.1023-1034 (DOI: 10.5059/yukigoseikyokaishi.75.1023)
Phototriggered Dehydration Condensation Using an Aminocyclopropenone
Kenji Mishiro, Yuki Yushima, Munetaka Kunishima
Organic letters 19 (18), pp 4912-4915 (DOI: 10.1021/acs.orglett.7b02383)
Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid
Yamada Kohei, Kamimura Naoto, Kunishima Munetaka
Beilstein Journal of Organic Chemistry 13, pp. 1478-1485 (DOI: 10.3762/bjoc.13.146)
N,N'-Dimethylated Benzyloxytriazinedione:A Stable Solid Reagent for Acid-Catalyzed O-Benzylation
Hikaru Fujita, Satoshi Kakuyama, Munetaka Kunishima
European Journal of Organic Chemistry (4), pp. 833-839 (DOI: 10.1002/ejoc.201601387)
Study of O-Allylation using Triazine-based Reagents
Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 65, pp. 112-115 (DOI: 10.1248/cpb.c16-00744)

2016Posted by admin

 
Alcohol- and Amine-Tolerant Synthesis of Six-Membered Cyclic Quaternary Ammonium Salts Using a Triazine-Based Reagent
Masanori Kitamura, Seina Yamamura, Kohei Yamada, Munetaka Kunishima
Asian Journal of Organic Chemistry 5 (12), pp. 1508-1517 (DOI: 10.1002/ajoc.201600429)
Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation
Kohei Yamada, Yukiko Karuo, Yuichi Tsukada, Munetaka Kunishima
Chemistry - A European Journal 22 (39), pp. 14042-14047 (DOI: 10.1002/chem.201603120)
Development of a Triazine-based tert-Butylating Reagent, TriAT-tBu
Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
European Journal of Organic Chemistry (23), pp. 4093-4098 (DOI: 10.1002/ejoc.201600663)
Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure
Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Masanori Kitamura, Munetaka Kunishima, Yasutsuna Sasaki, Yukio Kato
Pharmaceutical Research 33 (2), pp. 269-282 (DOI: 10.1007/s11095-015-1785-0)
Potent triazine-based dehydrocondensing reagents substituted by an amido group
Munetaka Kunishima, Daiki Kato, Nobu Kimura, Masanori Kitamura, Kohei Yamada, Kazuhito Hioki
Beilstein Journal of Organic Chemistry 12, pp. 1897-1903 (DOI: 10.3762/bjoc.12.179)
Development of Acid-Catalyzed Fluorous Benzylating Reagents Based on a Triazinedione Core
Munetaka Kunishima, Ryohei Asao, Kohei Yamada, Masanori Kitamura, Hikaru Fujita
Journal of Fluorine Chemistry 190, pp. 68-74 (DOI: 10.1016/j.jfluchem.2016.09.003)

2015Posted by admin

 
Study of the Reactivities of Acid-Catalyzed O-Benzylating Reagents Based on Structural Isomers of 1,3,5-Triazine
Hikaru Fujita, Naoko Hayakawa, and Munetaka Kunishima
Journal of Organic Chemistry 80 (21), pp. 11200-11205 (DOI: 10.1021/acs.joc.5b02059)
O-Benzylation of Carboxylic Acids Using 2,4,6-Tris(benzyloxy)-1,3,5-triazine (TriBOT) under Acidic or Thermal Conditions
Kohei Yamada, Saki Yoshida, Hikaru Fujita, Masanori Kitamura, and Munetaka Kunishima
European Journal of Organic Chemistry (36), pp. 7997-8002 (DOI: 10.1002/ejoc.201501172)

2014Posted by admin

 
Role of Linkers in Tertiary Amines that Mediate or Catalyze 1,3,5-Triazine-based Amide-forming Reactions
Masanori Kitamura, Fumitaka Kawasaki, Kouichi Ogawa, Shuichi Nakanishi, Hiroyuki Tanaka, Kohei Yamada, and Munetaka Kunishima
Journal of Organic Chemistry 79 (8), pp. 3709-3714 (DOI: 10.1021/jo500376m)
Synthesis of Pyrrolidinium Salts using a Triazine-based Reagent under Mild Conditions
Masanori Kitamura, Seina Yamamura, Hiroko Kobayashi, Mariko Yamamoto, Kayo Tada, Kazuhito Hioki, Kohei Yamada, and Munetaka Kunishima
Chemistry Letters 43 (10), pp. 1593-1595 (DOI: 10.1246/cl.140503)
Development of a New Benzylating Reagent Spontaneously Releasing Benzyl Cation Equivalents at Room Temperature
Kohei Yamada, Yuichi Tsukada, Yukiko Karuo, Masanori Kitamura, and Munetaka Kunishima
Chemistry - A European Journal 20 (38), pp. 12274-12278 (DOI: 10.1002/chem.201403158)
Specific Labeling of Streptavidin for Better Understanding of Ligand Modification in Modular Method for Affinity Labeling(MoAL)
Munetaka Kunishima, Daiki Kato, Shuichi Nakanishi, Masanori Kitamura, Kohei Yamada, Keiji Terao, and Tomoya Asano
Chemical and Pharmaceutical Bulletin 62 (11), pp. 1146-1150 (DOI: 10.1248/cpb.c14-00468)

2013Posted by admin

 
A Practical Method for p-Methoxybenzylation of Hydroxy Groups Using 2,4,6-Tris(p-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM)
Kohei Yamada, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
Synthesis 45 (21), pp. 2989-2997 (DOI: 10.1055/s-0033-1339713)
Study of 1,3,5-Triazine-Based Catalytic Amide-Forming Reactions: Effect of Solvents and Basicity of Reactants
Munetaka Kunishima, Masanori Kitamura, Hiroyuki Tanaka, Ichiro Nakakura, Takahiro Moriya, Kazuhito Hioki
Chemical and Pharmaceutical Bulletin 61 (8), pp. 882-886 (DOI: 10.1248/cpb.c13-00368)
Binding of sulforhodamine B to human serum albumin: A spectroscopic study
Masanori Kitamura, Koji Murakami, Kohei Yamada, Keiichi Kawai, Munetaka Kunishima
Dyes and Pigments 99, pp. 588-593 (DOI: 10.1016/j.dyepig.2013.06.011)
A New Method Using 2-Chloro-4,6-dimethoxy-1,3,5-triazine for Facile Elimination of Dimethylamino Group in Eschenmoserfs Methylenation for Synthesis of ƒΏ,ƒΐ-Unsaturated Esters
Kohei Yamada, Kazumasa Masaki, Yuri Hagimoto, Seina Kamiya, Munetaka Kunishima
Tetrahedron Letters 54, pp. 1758-1760 (DOI: 10.1016/j.tetlet.2013.01.092)

2012Posted by admin

 
Study on 1,3,5-Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species
Munetaka Kunishima, Takae Ujigawa, Yoshie Nagaoka, Chiho Kawachi, Kazuhito Hioki, Motoo Shiro
Chemistry - A European Journal 18, pp. 15856-15867 (DOI: 10.1002/chem.201202236.)
A novel acid-catalyzed O-benzylating reagent with the smallest unit of imidate structure
Kohei Yamada, Hikaru Fujita, Munetaka Kunishima
Organic Letters 14 (19), pp. 5026-5029 (DOI: 10.1021/ol302222p)
One-pot preparation of oxazol-5(4H)-ones from amino acids in aqueous solvents
Hikaru Fujita, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 60 (7), pp. 907-912 (DOI: 10.1248/cpb.c12-00291)
N-isopropyl-p-iodoamphetamine hydrochloride is predominantly metabolized by CYP2C19
Ken-ichi Fujita, Minako Sugiyama, Yuko Akiyama, Kazuhito Hioki, Munetaka Kunishima, Kodai Nishi, Masato Kobayashi, Keiichi Kawai and Yasutsuna Sasaki
Drug Metabolism and Disposition 40 (5), pp. 843-846 (DOI: 10.1124/dmd.111.043893)
Substrate-selective dehydrocondensation at the interface of micelles and emulsions of common surfactants
Kunishima, M., Kikuchi, K., Kawai, Y., Hioki, K.
Angewandte Chemie International Edition 51 (9), pp. 2080-2083 (DOI: 10.1002/anie.201107706)

2011Posted by admin

 
New approach to oligotriazoles using a cobalt complex of propargyl azides as a synthetic component
Yuichi Tsukada, Kohei Yamada, Munetaka Kunishima
Tetrahedron Letters 52 (26), pp. 3358-3360 (DOI: 10.1016/j.tetlet.2011.04.082)

2010Posted by admin

 
Labeling study of avidin by modular method for affinity labeling (MoAL)
Shuichi Nakanishi, Hiroyuki Tanaka, Kazuhito Hioki, Kohei Yamada, Munetaka Kunishima
Bioorganic and Medicinal Chemistry Letters 20 (23), pp. 7050-7053 (DOI: 10.1016/j.bmcl.2010.09.109)
Effects of stereochemistry and ƒΐ-substituents on the rates of vinylic SN2 reaction of hypervalent vinyl(phenyl)-ƒΙ3-iodanes with tetrabutylammonium halides
Kazunori Miyamoto, Takuji Okubo, Masaya Hirobe, Munetaka Kunishima, Masahito Ochiai
Tetrahedron 66 (31), pp. 5819-5826 (DOI: 10.1016/j.tet.2010.04.041)

2009Posted by admin

 
Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation
Munetaka Kunishima, Shuichi Nakanishi, Jin Nishida, Hiroyuki Tanaka, Daiki Morisaki, Kazuhito Hioki, Hiroshi Nomoto
Chemical Communications (37), pp. 5597-5599 (DOI: 10.1039/B912908A)
Synthesis of aza-bridged calix(4-methoxy)triazines toward flattened ƒΞ-conjugated macrocycles
Hiroyuki Tanaka, Ayako Wada, Motoo Shiro, Kazuhito Hioki, Daiki Morisaki, and Munetaka Kunishima
Heterocycles 79 (C), pp. 609-616 (DOI: 10.3987/COM-08-S(D)24)
A Simple Practical Method for the Synthesis of 4,6-Dimethoxy-1,3,5-triazin-2(1H)-one Using Dimethylamine-Functionalized Solid-Phase Reagents
Kazuhito Hioki, Keiichi Ohshima, Yuko Sota, Miki Tanaka, Munetaka Kunishima
Synthesis (4), pp. 542-544 (DOI: 10.1055/s-0028-1083330)