薬学類・創薬科学類,大学院薬学系ホームLaboratory & Faculty > Laboratory List > Membrane Transport and Pharmacokinetics

Membrane Transport and Pharmacokinetics

Main Research Interests

  • Role of transporters in drug efficacy and toxicity
  • Drug absorption and delivery
  • Renal and hepatic elimination
  • Uric acid transporters
  • Drug-drug interaction on transporters
  • Species difference of drug transporters
  • Regulation of transporter activity
  • Interaction between transporters and PDZ proteins
  • Transporter-related nonlinear pharmacokinetics
  • Drug-induced organ toxicity

Outlines of Researches

The key words of our research are, "Transporter", "Pharmacokinetics", and "Xenobiotics". More than 400 transporters are expressed in human and playing roles in regulating membrane permeation of various types of substances, including physiological compounds and xenobiotics such as clinically used drugs. Some transporters affect pharmacokinetic properties of drugs, and others are physiologically essential, since genetic mutation of those transporters directly related hereditary diseases. So, transporters are very potential as the novel targets for drug development, drug delivery and optimization of clinical dosage regimen.

Based on such background, following research themes are under investigation:

  1. Drug-induced toxicities.
    1. Uric acid transporters and drug-induced alteration of serum uric acid level.
    2. Drug-induced lung toxicity.
  2. Novel drug targets.
    1. Anticancer drugs targeting cancer-selective transporters.
    2. Markers of novel kidney function
    3. Inflammation related transporters
    4. Transporters regulating carnitine and related compounds
  3. Species differences in drug transporters.
    1. Hepatic OATP transporters
    2. Intestinal OATP and efflux transporters and bioavailability.
  4. Transporter-protein interaction.
    1. Roles of PDZ proteins in transport activity
    2. Identification of proteins interacting with transporters

Typical transporters under investigation are as follows:

  • Physiological Transporters: CTL, OCTNs, MCTs, NPT, PEPTs, PGT, SGLT, SMCT, URAT1.
  • Drug Transporters: OATPs, OATs, OCTs, BCRP, MDRs, MRPs.

Main References

Staffs

  • Ikumi TAMAI Professor

    Specialized field

    Membrane Transporters, Drug Absorption and Disposition

  • Takeo NAKANISHI Associate Professor

    Specialized field

    Pharmacokinetics, Biopharmaceutics(Membrane Transporter), Molecular Biology, Molecular Oncology

  • Komori Hisakazu Assistant Professor

    Specialized field

    Pharmacokinetics, Biopharmaceutics, Molecular Biology

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